Structure and Interaction of Intermediate FIlaments

Cross-polarized microscopy image of a neurofilament network in a quartz capillary. The network was self-assembled of recombinant NF-L protein. The nematic domain boundaries are a clear indication of the extended length scale of the ordered phase.

Structural Transition in Myelin Membrane as Initiator of Multiple Sclerosis

Congratulations to Rona and the rest of the team for the wonderful work published in PNAS! In her recent paper, Rona showed that myelin membranes can transition to multiple-sclerosis pathology by local environmental conditions such as elevated salt and temperature 

Phosphorylation-Induced Mechanical Regulation of Intrinsically Disordered Neurofilament Proteins

Congratulations to Eti, Micha and the rest of team for the wonderful work published in Biophysical Journal including an astonishing superhero cover! In the paper we show how phosphorylation manipulate neurofilament mechanics and macroscopic order.

Neurofilaments function as pneumatic shock absorbers: compression response arising from disordered proteins

Congratulations to Micha, Eti and the rest of team for the wonderful work published in PRL!
In the paper we show how disordered proteins control the compression response and the mechanoelastic properties of neuronal cytoskeleton.

Modern X-ray scattering studies of complex biological systems

Check out our recent review in Current Opinion in Biotechnology

X-ray scattering is one of the most prominent structural characterization techniques in biology. The key advantage of X-ray scattering is its ability to penetrate and weakly interact with the bare studied materials.