Goal

Our goal is to increase our appreciation of the biological processes that drive stress responses and to provide new avenues to develop therapeutic antifungal strategies.

Fluconazole-resistant C. albicans, James Archer

Approach

We take an interdisciplinary approach using genetics, genomics, cell biology, clinical microbiology, biochemistry and chemistry to address questions of how cells grow, divide, and change under a range of conditions.

C. albicans hyphal formation, Carol Wells

Selected open questions

How do pathogenic yeast cells survive, divide and grow in the presence of antifungal cells? What molecular and genetic mechanisms drive the rapid appearance of ploidy shifts and aneuploidy? How do different chromosome and cellular components facilitate rapid adaptation to drug?

Budding C. albicans, Maxine Jalbert & Leo Kaufman