Specific internalization of targeted lipid-based nanoparticles to mantle cell lymphoma (MCL) cells

aCD38 lipid-nanoparticles internalized (LNPs) specifically to MCL cells (right panel).
Isotype-LNPs do not internalized to MCL cells (left panel)

Particles insides particles

SEM analysis of PLGA particles entrapping immunogenic peptide.


Ovarian cancer cells surface morphology visualized by scanning electron micrograph (SEM).

Transmission electron microscopy of mantle cell lymphoma exosomes

Mantle cell lymphoma patients’ exosomes were isolated from the culture media of MCL cells and analyzed by transmission electron microscopy (TEM) and immuno-electron microscopywith anti-CD81 followed by IgG 12-nm in diameter gold nanoparticle conjugated mAb.