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Education

2009-2010 Post Doctorat
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel.
Thesis: Characterizing the translation initiation machinery of the TISU element.
Supervisor: Rivka Dikstein

2004-2009 Ph.D.
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel.
Thesis: Transcription and Translation Initiation in a Subset of TATA-less Genes.
Supervisor: Prof. Rivka Dikstein.

2001-2003 M.Sc.
The George S. Wise Faculty of Life Science Department of Cell Research and Immunology, Tel Aviv University.
Thesis: Synthesis and Biological Evaluation of H23-Paclitaxel Immunoconjugate.
Supervisors: Prof. Iafa Keydar, Dr. Nechama I. Smorodinsky and Prof. Daniel H. Wreschner.

1998-2001 B.Sc.
The Faculty of Life Science, Ben Gurion University of the Negev.

Position & Employment

2011- Quiet Therapeutics- a startup for drug delivery, Weizmann Science Park, Ness Ziona. Consultant for molecular Biology, establishing molecular biology assays and performing pharmaceutical studies

2001-2003
Teaching assistant in molecular biology, Life Science faculty, Tel Aviv University.

2000-2001
Technician in the laboratories of Molecular Biology (PCR), Endocrinology, Hematology and at the Center of AIDS research, Kaplan Hospital, Rehovot.

Publications

1. Moshonov, S., Elfakess, R., Golan-Mashiach, M., Sinvani, H., and Dikstein, R. (2008) Links between core promoter and basic gene features influence gene expression. BMC Genomics 9, 92.

2. Elfakess R, Dikstein R.(2008) A translation initiation element specific to mRNAs with very short 5'UTR that also regulates transcription. PLoS ONE 3, e3094.

3. Yarden G.*, Elfakess R.*, and Dikstein, R. (2009) Characterization of sINR, a strict version of the Initiator core promoter element. Nucleic Acids Res. 37(13):4234-46. *Equal contributors.

4. Gazit, K., Moshonov, S., Elfakess, R. Sharon, M., Mengus, G., Davidson, I. and Dikstein, R. (2009) TAF4/4b-TAF12 DNA binding facilitates Initiator core promoter function in a subset of genes. J Biol Chem. 284(39):26286-26296.

5. Elfakess R, Peer D. (2010) Overcoming RNAi transduction in leukocytes using targeted and stabilized nanoparticles. IDrugs. 13(9):626-631. PDF

6. Elfakess R*, Hadar Sinvani*, Ora Haimov, Yuri Svitkin, Nahum Sonenberg and Rivka Dikstein (2011). Unique translation initiation of mRNAs with Translation Initiator of Short 5'UTR element is adapted to metabolic energy stress. Nucleic Acids Res. 39(17):7598-609. *Equal contributors.

7. Michal Golan-Mashiach, Moshe Grunspan, Rafi Emmanuel, Liron Gibbs-Bar, Rivka Dikstein and Ehud Shapiro (2012). Identification of CTCF as a master regulator of the clustered protocadherin genes. Nucleic Acids Res. 40(8):3378-3391

8. Shiri Weinstein, Rafi Emmanuel, Ashley M. Jacobi, Avigdor Abraham, Mark A. Behlke, Andrew Sprague, Tatiana I. Novobrantseva, Arnon Nagler and Dan Peer. (2012). RNA Inhibition Highlights Cyclin D1 as a Potential Therapeutic Target for Mantle Cell Lymphoma. PLoS ONE 7(8): e43343. PDF

9. Emmanuel R., Weinstein S., Landesman-Milo D. and Peer D (2013). eiF3c: A potential therapeutic target for cancer. Cancer Letters. 336:158-166. PDF

10. Cohen K, Emmanuel R., Kisin-Finfer E., Shabat D., and Peer, D. (2014). Modulation of Drug Resistance in Ovarian Adenocarcinoma using Chemotherapy Entrapped in Hyaluronan-Grafted Nanoparticle Clusters. ACS Nano. 8(3), 2183-2195. PDF