The Perlson Molecular Neurodegeneration Research Group
Neuron cell death and synapse disruption seen in neurodegenerative diseases like Amyotrophic Lateral Sclerosis (ALS) is a non-cell-autonomous process and involve a multi system progression. As neurons are highly polarized cells with very long axons, inorder to maintain healthy and function properly neurons depends on accurate and efficient long distance communication mechanism.
The long-term goal of the lab is to elucidate the molecular communication mechanisms in the neuron and between the neuron to its environment. More specifically, we wish to understand how the long distance signaling process is regulated and what information is required to maintain healthy nerve cells.
To achieve this, we are trying to solve questions such as: Why do alterations in this information lead to neurodegenerative disease? What are the delivery mechanisms for long-distance signaling? How do nerve cells coordinate this information? How does the information know how to get to the right place at the right time?