In collaboration with the Sourasky Medical Center we are conducting a clinical trial where Familial Adenomatous Polyposis (FAP) patients are treated with macrolides to restore APC expression. FAP is an inherited colorectal cancer caused by an APC germline mutation which leads to a somatic mutation and thus APC loss of function. All FAP patients develop colonic adenomas which progress to cancer if not removed. In our clinical trial FAP patients with identified nonsense mutations are treated and adenomas are monitored and extracted for testing. We analyze adenoma samples in a variety of genetic and biochemical methods such as NGS, q-RT-PCR, WB etc. Organoids are also grown from theses adenoma samples.