Although the Wnt signaling pathway has been extensively studied over the years, new Wnt regulators are constantly being discovered. Aldolase, EDD, HTRA1, CPE and 14-3-3 are some of the new Wnt signaling regulators that were isolated and characterized in our lab.
We utilize different screening approaches in order to identify novel components of the Wnt cascade.
14-3-3: https://www.ncbi.nlm.nih.gov/pubmed/24721736
EDD: https://www.ncbi.nlm.nih.gov/pubmed/21118991
CPE: https://www.ncbi.nlm.nih.gov/pubmed/27375026
https://www.ncbi.nlm.nih.gov/pubmed/22824791