RBCs are anucleated cells that also lack all other organelles and function as oxygen carriers.The RBC membrane contains proteins and lipids arranged in a special complex that underlies the cell membrane. This network provides deformability on one hand and stability on the other, a characteristic which is crucial for the cells movement in the capillary network.
We have recently raveled a novel function of the Wnt ligands in extending RBCs survival in storage and following blood transfusion.
Currently we are defining the exact mechanism underling this Wnt-induced activity and determine its biological importance.
A new projects studying the effects of Wnts on white blood cells is revealing novel affects of signaling pathways in the circulation.