In collaboration with: Dr. Danielle Bendayan, Lung division, Shmuel Harofe Hospital, Dr. Oren Zimchoni, Kaplan Hospital
Mycobacterium Tuberculosis (MTb) is the cause of Tuberculosis disease and is the top infectious agent world wide according to the WHO. In the last century a MTb was successfully controlled with highly efficient antibiotic treatment. However, recently the number of antibiotic-resistant MTb cases increased dramatically.
Our goal is to characterize and B cell response to Mtb and isolate anti-mob inhibiting antibodies that in the future can be translated into new antibody-based therapeutics, diagnostics and vaccine candidates for MTb. For that, we isolate and characterize the antibodies that are naturally produced in response to MTb in infected individuals.